TY - CHAP M1 - Book, Section TI - Mucociliary Clearance A1 - Dickey, Burton F. A1 - Knowles, Michael R. A1 - Boucher, Richard C. A2 - Grippi, Michael A. A2 - Elias, Jack A. A2 - Fishman, Jay A. A2 - Kotloff, Robert M. A2 - Pack, Allan I. A2 - Senior, Robert M. A2 - Siegel, Mark D. PY - 2015 T2 - Fishman's Pulmonary Diseases and Disorders, 5e AB - Mucus forms an essential barrier that protects the lungs from inhaled particles, pathogens, and toxicants. However, excessive mucus accumulation contributes to the pathogenesis of all the common diseases of the airways. Therefore, understanding airway mucus function and dysfunction is important for pulmonary medicine. The airway mucus barrier is mobile, continually propelled in a proximal direction by ciliary beating. Ciliary dysfunction causes disease both because of the failure to clear xenobiotics from the lungs and because it results in mucus accumulation. Mucus and ciliary biology will be considered together in this chapter as they interact to achieve, or fail to achieve, airway clearance. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1122354533 ER -