TY  - CHAP
M1  - Book, Section
TI  - The Transplant Patient
A1  - Munshi, Laveena
A1  - Scales, Damon C.
A1  - Granton, John T.
A2  - Hall, Jesse B.
A2  - Schmidt, Gregory A.
A2  - Kress, John P.
PY  - 2015
T2  - Principles of Critical Care, 4e
AB  - Advancements  in  immunosuppression,  transplant  techniques,  antimicrobials,  postoperative  management  and  support,  bridging  techniques,  and  extracorporeal  life  support  have  had  an  enormous  impact  on  morbidity  and  mortality  of  transplant  recipients  over  the  past  few  decades.Although  some  generalizations  can  be  made  regarding  the  management  of  transplant  patients,  organ-specific  considerations  based  on  the  particular  allograft  transplanted  are  critically  important.Infections  can  reactivate  in  an  immunocompromised  recipient  who  has  been  previously  exposed.  Alternatively,  a  naïve  recipient  may  acquire  an  infection  following  the  transplant  of  an  organ  from  a  seropositive  donor.  Infections  in  transplant  recipients  can  progress  rapidly  and  hence  must  be  promptly  recognized  and  appropriately  treated.Risks  and  benefits  of  sustained  immunosuppressive  therapy  must  be  balanced  in  transplant  recipients.  Though  immunosuppressive  drugs  are  essential  to  prevent  allograft  rejection,  they  also  increase  the  risk  of  infection  and  neoplasm.Immunosuppressive  drugs  have  significant  side  effects  and  many  have  important  drug-drug  interactions  that  must  be  recognized  by  the  intensivist.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1107712769
ER  -