TY - CHAP M1 - Book, Section TI - Approach to the Patient with Gastrointestinal Disease A1 - Hasler, William L. A1 - Owyang, Chung A2 - Kasper, Dennis A2 - Fauci, Anthony A2 - Hauser, Stephen A2 - Longo, Dan A2 - Jameson, J. Larry A2 - Loscalzo, Joseph PY - 2014 T2 - Harrison's Principles of Internal Medicine, 19e AB - The gastrointestinal (GI) tract extends from the mouth to the anus and is composed of several organs with distinct functions. Specialized independently controlled thickened sphincters that assist in gut compartmentalization separate the organs. The gut wall is organized into well-defined layers that contribute to functional activities in each region. The mucosa is a barrier to luminal contents or a site for transfer of fluids or nutrients. Gut smooth muscle in association with the enteric nervous system mediates propulsion from one region to the next. Many GI organs possess a serosal layer that provides a supportive foundation but that also permits external input. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2021/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1120810257 ER -