TY - CHAP M1 - Book, Section TI - Mechanical Ventilatory Support A1 - Celli, Bartolome R. A2 - Kasper, Dennis A2 - Fauci, Anthony A2 - Hauser, Stephen A2 - Longo, Dan A2 - Jameson, J. Larry A2 - Loscalzo, Joseph PY - 2014 T2 - Harrison's Principles of Internal Medicine, 19e AB - Mechanical ventilation is used to assist or replace spontaneous breathing. It is implemented with special devices that can support ventilatory function and improve oxygenation through the application of high-oxygen-content gas and positive pressure. The primary indication for initiation of mechanical ventilation is respiratory failure, of which there are two basic types: (1) hypoxemic, which is present when arterial O2 saturation (Sao2) 50 mmHg) resulting from conditions that decrease minute ventilation or increase physiologic dead space such that alveolar ventilation is inadequate to meet metabolic demands. When respiratory failure is chronic, neither of the two types is obligatorily treated with mechanical ventilation, but when it is acute, mechanical ventilation may be lifesaving. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2022/05/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1120808698 ER -