TY  - CHAP
M1  - Book, Section
TI  - Chemokines, Adipokines, and Growth Factors in the Lung
A1  - Butler, Marcus W.
A1  - McLoughlin, Paul
A1  - Keane, Michael P.
A2  - Grippi, Michael A.
A2  - Elias, Jack A.
A2  - Fishman, Jay A.
A2  - Kotloff, Robert M.
A2  - Pack, Allan I.
A2  - Senior, Robert M.
A2  - Siegel, Mark D.
PY  - 2015
T2  - Fishman's Pulmonary Diseases and Disorders, 5e
AB  - Normal  development  of  organ  systems,  including  the  lungs,  in  utero,  during  subsequent  maturation  into  adulthood,  and  in  health  throughout  life,  requires  intricate  signals  to  be  exchanged  among  various  tissues,  capable  of  permitting  diversity  and  adaptation  in  differing  cellular  and  extracellular  contexts,  while  being  robust  to  onslaughts  from  ever-changing  environmental  stimuli.  Among  the  mediators  involved  in  such  complex  cellular  signaling,  and  relevant  in  the  setting  of  many  pulmonary  disorders,  are  chemokines  and  growth  factors.  There  has  been  further  complexity  added  with  increasing  recognition  of  adipose  tissue  as  a  source  of  systemic  bioactive  mediators  called  adipokines,  that  impact  on  lung  health.  While  some  of  these  mediators  are  implicated  in  the  development  of  disease  states,  they  are  more  often  than  not  also  critical  to  tissue  homeostasis,  and  are  challenging  target  systems  for  therapeutic  manipulation.  Nonetheless,  we  are  now  in  an  era  of  exciting  developments  in  targeted  biologic  therapies  that  offer  the  potential  for  substantial  progress  in  the  fight  against  difficult-to-treat  pulmonary  disorders  characterized  by  pathogenic  processes  including  acute  and  chronic  inflammation,  fibrosis,  vascular  remodeling,  and  neoplasia.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1122356319
ER  -