TY - CHAP M1 - Book, Section TI - Overview of the Anemias A1 - Bunn, H. Franklin A2 - Bunn, H. Franklin A2 - Aster, Jon C. PY - 2011 T2 - Pathophysiology of Blood Disorders AB - LEARNING OBJECTIVESAfter studying this chapter you should:Understand how anemia impacts oxygen transport and the ways in which anemic patients compensate for decreased oxygen-carrying capacity.Develop a coherent approach to the clinical and laboratory evaluation of patients with anemia.Understand and use classification of anemia based on production versus destruction and on red cell size (mean cell volume).Be able to explain the phenomenon of ineffective erythropoiesis—its diagnosis and role in pathogenesis.Understand the process by which red cells are broken down, the catabolism of heme in macrophages, and the transport of bilirubin in the plasma and its conjugation in the liver. SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/10/13 UR - accessmedicine.mhmedical.com/content.aspx?aid=1104130828 ER -