TY - CHAP M1 - Book, Section TI - Familial Autoinflammatory Diseases A1 - Grandemange, Sylvie A1 - Kone-Paut, Isabelle A1 - Touitou, Isabelle A2 - Murray, Michael F. A2 - Babyatsky, Mark W. A2 - Giovanni, Monica A. A2 - Alkuraya, Fowzan S. A2 - Stewart, Douglas R. PY - 2014 T2 - Clinical Genomics: Practical Applications in Adult Patient Care AB - Disease summary:Autoinflammatory diseases (AIDs) are illnesses of the innate immune system without high-titer autoantibodies or antigen-specific T cells in contrast to autoimmune diseases that relate to a deficit of acquired immunity. These diseases are characterized by recurrent fever and systemic inflammation, and the main complication is the risk of generalized or renal amyloidosis in untreated patients. Other sporadic, undefined, or complex disorders have been also linked to the AIDs group. This review will focus on hereditary recurrent fevers (HRFs).Hereditary basis:Both dominant and recessive autosomal transmission, with incomplete penetranceDifferential diagnosis:Nonhereditary recurrent fevers, for example, PFAPA syndrome (Marshall syndrome) SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1102702400 ER -