TY - CHAP M1 - Book, Section TI - Chapter 21. Systemic Lupus Erythematosus A1 - Dall'Era, Maria A2 - Imboden, John B. A2 - Hellmann, David B. A2 - Stone, John H. PY - 2013 T2 - CURRENT Diagnosis & Treatment: Rheumatology, 3e AB - Predilection for females of childbearing age.Multisystem disease, often with a relapsing-remitting course.Photosensitive rash, polyarthritis, serositis, and fatigue are common manifestations of disease flares.Renal disease and central nervous system involvement are important causes of morbidity.Presence of antinuclear antibodies.Certain autoantibodies (anti-dsDNA and anti-Sm) have great specificity for the diagnosis of SLE, but lack sensitivity.Hypocomplementemia may occur during flares. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/25 UR - accessmedicine.mhmedical.com/content.aspx?aid=57272268 ER -