TY - CHAP M1 - Book, Section TI - Chapter 19. High-Frequency Ventilation A1 - Froese, Alison B. A1 - Ferguson, Niall D. A2 - Tobin, Martin J. PY - 2013 T2 - Principles and Practice of Mechanical Ventilation, 3e AB - High-frequency ventilation has been an unconventional option for more than three decades and during that period several varieties of high-frequency ventilators have come and gone. Currently, interest in high-frequency ventilation in adult critical care is part of a larger search for ventilator strategies that can support gas exchange in the severely hypoxemic patient without contributing additional ventilator-induced lung injury. Over the past 30 years, high-frequency ventilators provided an experimental tool that identified many of the mechanisms that contribute to ventilator-induced lung injury. It became clear that ventilator-induced lung injury is minimized by ventilator patterns that achieve homogeneous aeration of as much of the lung as possible, avoiding both injury from overdistension (volutrauma) and that arising from the repetitive opening and closing of lung units in regions of atelectasis (atelectrauma) (Fig. 19-1).1 Failure to operate in the “safe zone” initiates biotrauma.2,3 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=57067290 ER -