TY - CHAP M1 - Book, Section TI - Chapter 233. Immunosuppressive and Immunomodulatory Drugs A1 - Callen, Jeffrey P. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintImmunosuppressive and Immunomodulatory Drugs at a GlanceThe main goals in immunotherapy are safety and effectiveness.Unlike immunomodulators, immunosuppressive drugs are all characterized by a narrow therapeutic window requiring precise dosing and close side-effect monitoring.The highest level of safety and effectiveness in immunotherapy therapy is currently accomplished by the use of combined regimens.An additive or synergistic combined immunotherapeutic regimen allows significant reduction of dose-dependent drug side effects maintaining or improving the effectiveness, respectively.A comprehensive knowledge of the pathophysiology of the treating disease as well as of the pharmacokinetics and pharmacodynamics concepts is crucial for delineating the most effective and safest therapeutic regimens. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=56102014 ER -