TY - CHAP M1 - Book, Section TI - Chapter 221. Topical Immunomodulators A1 - Esparza, Edward M. A1 - Sidbury, Robert A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - Topical immunomodulators are nonsteroidal agents that target the immune system for therapeutic effect in the skin. The macrolactams, pimecrolimus and tacrolimus, act as anti-inflammatory agents by binding immunophilin and inhibiting cytokine production. The imidazoquinoline amine, imiquimod, induces interferon (IFN) production and enhances immune responses, although several more potent analogs are under clinical investigation. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/10/06 UR - accessmedicine.mhmedical.com/content.aspx?aid=56097730 ER -