TY - CHAP M1 - Book, Section TI - Chapter 200. Syphilis A1 - Katz, Kenneth A. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintSyphilis at a GlanceA disease caused by the spirochete Treponema pallidum subspecies pallidum that is usually sexually transmitted.In the United States, syphilis disproportionately affects men who have sex with men and blacks.The most common and recognizable manifestations are usually cutaneous.Syphilis passes through four distinct clinical phases: Primary stage, characterized by a chancre.Secondary stage, characterized typically by skin eruption(s) with or without lymphadenopathy and organ disease.A latent period of varied duration, characterized by the absence of signs or symptoms of disease, with only reactive serologic tests as evidence of infection.Tertiary stage, with cutaneous, neurologic, or cardiovascular manifestations.The recommended treatment for most types of syphilis is benzathine penicillin G, with dose and administration schedule determined by disease stage.Persons with human immunodeficiency virus infection are at higher risk of treatment failure and to neurosyphilis. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/25 UR - accessmedicine.mhmedical.com/content.aspx?aid=56090705 ER -