TY - CHAP M1 - Book, Section TI - Chapter 191. General Considerations of Viral Diseases A1 - Morrison, L. Katie A1 - Ahmed, Ammar A1 - Madkan, Vandana A1 - Mendoza, Natalia A1 - Tyring, Stephen A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintViral Diseases at a GlanceCutaneous lesions are an extremely common and often the only manifestation of viral infections.Viruses can produce skin lesions by direct replication in the epidermis, as is the case with papillomaviruses, poxviruses, and several herpesviruses; or as a secondary manifestation of replication elsewhere in the body.The direct effects of viral replication on epidermal cells and the inflammatory immune response both contribute to cutaneous lesions.Viral latency followed by reactivation occurs with certain viruses. Neoplastic transformation is possible with some latent viruses.Laboratory diagnostic techniques include viral culture, microscopy, detection of viral nucleic acids or viral antigens, and serologic testing.Many effective antiviral drugs exist, and others are currently in development.Preventive techniques are currently the most effective means for decreasing the morbidity of viral infections. Vaccines are a key component of preventative measures. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=56086972 ER -