TY  - CHAP
M1  - Book, Section
TI  - Chapter 154. Mechanisms of Autoimmune Disease
A1  - Kang, Insoo
A1  - Craft, Joseph
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
PY  - 2012
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintMechanisms  for  Autoimmune  Diseases  at  a  GlanceAutoimmune  diseases  are  relatively  common  disorders  and  can  be  divided  into  organ-specific  and  systemic  autoimmune  diseases  based  on  the  autoantigens  targeted  by  immune  cells.Although  the  underlying  etiologies  of  these  illnesses  are  still  elusive,  they  arise  in  the  context  of  a  break  in  the  immune  tolerance  to  self.The  mechanisms  for  abrogation  of  immune  self-tolerance  appear  to  be  multifactorial,  including  genetic  and  environmental,  that  lead  to  unregulated  immune  activation  against  self-antigens  and  subsequent  tissue  destruction.B  cells  and  T  cells  recognize  self-antigens  and  dominate  the  phenotype  of  the  patient  with  autoimmunity,  although  other  immune  components  including  antigen-presenting  cells  and  complement  are  involved  in  various  steps  from  initiation  of  the  autoimmune  response  to  tissue  destruction.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56075507
ER  -