TY - CHAP M1 - Book, Section TI - Chapter 149. Mastocytosis A1 - Tharp, Michael D. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintMastocytosis at a GlanceThe hallmark of mastocytosis is a pathologic accumulation of mast cells in tissues.Mastocytosis occurs at any age.The skin is the most commonly involved organ system.Cutaneous findings consist of hyperpigmented macules, papules or nodules, or a diffuse infiltration of the dermis.Generally benign in children.In adults, most commonly associated with a somatic activating mutation of c-kit (codons 816 and 560).Cutaneous manifestations may occur alone or in association with systemic disease.Related features may be flushing, pruritus, hypotension, nausea, dyspepsia, and diarrhea.Most common extracutaneous tissues involved are the bone marrow, liver, spleen, and lymph nodes.May be associated with myeloproliferative and myelodysplastic disorders.Classification of mastocytosis is critical for prognosis and treatment. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/11/03 UR - accessmedicine.mhmedical.com/content.aspx?aid=56073159 ER -