TY  - CHAP
M1  - Book, Section
TI  - Chapter 141. The Neurofibromatoses
A1  - Listernick, Robert
A1  - Charrow, Joel
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
PY  - 2012
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintNeurofibromatosis  Type  1  at  a  GlanceAutosomal  dominant  condition  with  incidence  of  1  in  3,000  live  births.Diagnosed  clinically  if  two  major  features  are  present  (see  Table  141-1).Cutaneous  neurofibromas:Softer  than  the  surrounding  connective  tissue  and  protrude  just  above  the  skin  surface  or  lie  just  under  the  skin  with  an  overlying  violaceous  hue.Subcutaneous  neurofibromas:Arise  from  peripheral  nerves,  both  under  the  skin  and  deep  in  the  viscera.Generally  much  harder.Plexiform  neurofibromas:Generally  present  at  birth  or  apparent  during  the  first  several  years  of  life.May  lead  to  disfigurement,  blindness  (secondary  to  amblyopia,  glaucoma,  or  proptosis),  loss  of  limb  function,  or  organ  dysfunction  by  compression  of  vital  structures.Segmental  neurofibromatosis  type  1  (NF-1):Manifestations  of  NF-1,  usually  limited  to  one  area  of  the  body.Occurs  as  result  of  a  postconceptional  mutation  in  the  NF-1  gene,  leading  to  somatic  mosaicism.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56070287
ER  -