TY - CHAP M1 - Book, Section TI - Chapter 140. Tuberous Sclerosis Complex A1 - Darling, Thomas N. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintTuberous Sclerosis Complex at a GlanceAutosomal dominant syndrome with variable expressivity.Manifested by hamartomatous tumors in multiple organs, including brain (causing seizures), eyes, heart, kidneys, lungs, and skin.Skin lesions occur in nearly all individuals and are important for diagnosis.Skin lesions include hypomelanotic macules, “confetti” lesions, facial angiofibromas, fibrous facial plaque, shagreen patch, and ungual fibromas.Hypomelanotic macules appear at birth or shortly thereafter and are most useful in early diagnosis.Although the skin lesions are benign, they may require treatment due to symptoms or disfigurement. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=56070051 ER -