TY - CHAP M1 - Book, Section TI - Chapter 124. Cutaneous Melanoma A1 - Bailey, Evans C. A1 - Sober, Arthur J. A1 - Tsao, Hensin A1 - Mihm, Martin C. A1 - Johnson, Timothy M. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintMelanoma at a GlanceRising incidence worldwide; United States estimated lifetime risk of developing invasive melanoma is 1:1,500 if born in 1935, 1:600 if born in 1960, 1:62 if born in 2006, and 1:50 if born in 2010 (1:30 with inclusion of in situ melanoma).Risk factors include history of sunburns and/or heavy sun exposure, blue or green eyes, blonde or red hair, fair complexion, >100 typical nevi, any atypical nevi, prior personal or family history of melanoma, or p16 mutation.Mean age of diagnosis is 52 years, 10–15 years younger than other more common cancers of the breast, lung, colon, and prostate.Most common location is the back for men, and lower extremities followed by trunk for women but can occur anywhere on the skin surface.Features used for melanoma recognition: A (asymmetry), B (irregular borders), C (color variegation), D (diameter >6 mm in most common use, but others have changed D to difference—“ugly duckling” sign or different with respect to change in size, shape, color, or persistent lesional pruritus), and E (evolving over time).Follows a highly variable course and represents a heterogeneous disorder; surgically curable if diagnosed and treated in early phase, but potentially lethal with increased risk when diagnosed and treated late. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=56062430 ER -