TY - CHAP M1 - Book, Section TI - Chapter 110. Genome Instability, DNA Repair, and Cancer A1 - RĂ¼nger, Thomas M. A1 - Kraemer, Kenneth H. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintGenome Instability, DNA Repair, and Cancer at a GlanceDNA can be damaged by physical agents (ultraviolet or ionizing radiation) or chemical agents in the environment.DNA damage may lead to mutations (changes in DNA sequence).The ability of cells to repair DNA damage and to maintain genome stability is of utmost importance to prevent malignant transformation.Different agents induce different types of DNA damage, which in turn require different responses and repair pathways.A number of hereditary disorders are characterized by genome instability due to defects in genes involved in DNA repair or DNA damage signaling.Many different laboratory tests can be used to diagnose genome instability and/or DNA repair defects.Inherited or acquired genome instability is associated with an increased cancer risk. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=56057161 ER -