TY - CHAP M1 - Book, Section TI - Chapter 83. Biology of Eccrine and Apocrine Glands A1 - Mauro, Theodora M. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintSweating at a GlanceHumans have 2–24 million sweat glands.Up to 10 L/day of sweat is produced by acclimatized individuals.The three eccrine cell types are (1) clear (secretory), (2) dark (mucoid), and (3) myoepithelial (contractile).Hypothalamic temperature is the strongest stimulus for sweating.Acetylcholine is the major stimulus secreted by sympathetic nerves.Botulinum toxin inhibits sweating by preventing acetylcholine release.Oxidative metabolism of glucose is a major source of eccrine gland adenosine triphosphate.Ductal reabsorption conserves NaCl.In individuals with cystic fibrosis, mutated chloride channels increase NaCl loss.Bacteria are necessary for apocrine odor.Odiferous precursors secretion is controlled by the MRP8 encoded by ABCC11.Adrenergic stimulation controls apocrine gland secretion. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/10/06 UR - accessmedicine.mhmedical.com/content.aspx?aid=56047872 ER -