TY - CHAP M1 - Book, Section TI - Chapter 76. Biology and Pathology of the Oral Cavity A1 - Woo, Sook-Bin A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintOral Mucosal Disease at a GlanceIdiopathic recurrent aphthous ulcers affect 15%–20% of the population; severe cases can be debilitating.Oral ulcers may also be associated with Crohn disease and other gastrointestinal disorders or due to herpes simplex, other viral infections, vasculitis, or other autoimmune disorders.Candidiasis of the oral cavity is common and painful. Predisposing factors include immunosuppression, hyposalivation, and use of steroids or antibiotics.Hair leukoplakia is due to Epstein–Barr viral infection and may be the presenting sign of HIV/AIDS.Oral lichen planus (LP) and lichenoid reactions affect 1%–2% of the population and are the most common cause of desquamative gingivitis; LP probably reflects a hypersensitivity response to endogenous or exogenous antigens.Leukoplakia is a premalignant condition associated with smoking and/or alcohol ingestion that must be distinguished from LP and benign frictional keratoses.Bullous diseases that affect the mouth include pemphigus, pemphigoid, and lupus erythematous.Intraoral pigmented lesions include nevi, postinflammatory hyperpigmentation, drug reactions, tattoos, and rarely melanoma. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/09/10 UR - accessmedicine.mhmedical.com/content.aspx?aid=56044576 ER -