TY - CHAP M1 - Book, Section TI - Chapter 72. Biology of Melanocytes A1 - Park, Hee-Young A1 - Yaar, Mina A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintBiology of Melanocytes at a GlanceMelanoblastsderive from the neural crest. Their migration/survival in the epidermis is influenced by numerous factors.Melanocytes populate the epidermis, hair follicle, eye, cochlea, and meninges.synthesize melanin, an indole derivative of 3,4 di-hydroxy-phenylalanine (DOPA) that is stored in melanosomes.are influenced by endocrine, paracrine, and autocrine factors and by ultraviolet (UV) irradiation.Melanosomesdisplay four maturation stages.contain structural matrix proteins, melanogenic enzymes, pH-maintaining proteins, and free-radical scavengers.are transported to melanocyte dendrite tips and transferred to epidermal keratinocytes.in skin, absorb UV radiation and protect against photodamage. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=56042365 ER -