TY  - CHAP
M1  - Book, Section
TI  - Chapter 63. Collagens, Elastic Fibers, and Other Extracellular Matrix Proteins of the Dermis
A1  - Krieg, Thomas
A1  - Aumailley, Monique
A1  - Koch, Manuel
A1  - Chu, Mon-Li
A1  - Uitto, Jouni
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
PY  - 2012
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintCollagens,  Elastic  Fibers  and  Other  Extracellular  Matrix  Proteins  of  the  Dermis  at  a  GlanceThe  extracellular  matrix  (ECM)  is  a  complex  network  composed  of  a  large  number  of  components,  which  determines  tissue  stiffness,  compliance,  and  resilience.ECM  proteins  (i.e.,  collagens,  proteoglycans,  glycoproteins)  consist  of  structural  domains  with  different  biological  functions.ECM  signals  control  cell  differentiation,  polarity,  migration,  survival,  and  expression  of  specific  genes.There  are  many  ECM-associated  heritable  diseases.  The  molecular  mechanisms  responsible  for  the  resulting  phenotypes  are  often  complex  and  involve  several  different  cellular  pathways.The  dynamic  balance  between  ECM  synthesis  and  degradation  is  critical  for  many  acquired  disease  processes,  i.e.,  tumor  invasion  and  metastasis,  fibrosis,  and  inflammatory  pathologies.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56039266
ER  -