TY  - CHAP
M1  - Book, Section
TI  - Chapter 54. Pemphigus
A1  - Payne, Aimee S.
A1  - Stanley, John R.
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
PY  - 2012
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintPemphigus  at  a  GlanceTwo  major  types:  pemphigus  vulgaris  and  pemphigus  foliaceus.Pemphigus  vulgaris:  erosions  on  mucous  membranes  and  skin;  flaccid  blisters  on  skin.Pemphigus  foliaceus:  crusted,  scaly  skin  lesions.Diagnosis  depends  on  histology  showing  intraepidermal  acantholysis  and  immunofluorescence  studies  documenting  the  presence  of  cell  surface  autoantibodies,  either  bound  to  patient  skin  or  in  the  serum.Pemphigus  vulgaris  histology:  suprabasal  acantholysis.Pemphigus  foliaceus  histology:  subcorneal  acantholysis.Direct  immunofluorescence  shows  immunoglobulin  G  (IgG)  on  the  keratinocyte  cell  surface  of  the  patient's  skin;  indirect  immunofluorescence  shows  IgG  in  patient  serum  that  binds  the  cell  surface  of  normal  keratinocytes.Autoantigens  are  desmogleins,  transmembrane  desmosomal  adhesion  molecules.Therapy  includes  topical  and  systemic  corticosteroids  and  immunosuppressive  agents.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/20
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56037338
ER  -