TY  - CHAP
M1  - Book, Section
TI  - Chapter 40. Epidermal Necrolysis (Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis)
A1  - Valeyrie-Allanore, L.
A1  - Roujeau, Jean-Claude
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
PY  - 2012
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintEpidermal  Necrolysis  at  a  GlanceRare  and  life-threatening  reaction,  mainly  drug  induced.Widespread  apoptosis  of  keratinocytes  provoked  by  the  activation  of  a  cell-mediated  cytotoxic  reaction  and  amplified  by  cytokines,  mainly  granulysin.Confluent  purpuric  and  erythematous  macules  evolving  to  flaccid  blisters  and  epidermal  detachment  predominating  on  the  trunk  and  upper  limbs  and  associated  with  mucous  membrane  involvement.Pathologic  analysis  shows  full-thickness  necrosis  of  epidermis  associated  with  mild  mononuclear  cell  infiltrate.  A  dozen  “high-risk”  drugs  account  for  one  half  of  cases.Up  to  20%  of  cases  remain  idiopathic.Early  identification  and  withdrawal  of  suspect  drugs  are  essential  for  good  patient  outcome.Treatment  is  mainly  symptomatic.  Sequelae  are  nearly  constant,  needing  systematic  follow-up  examinations.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/23
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56033128
ER  -