TY - CHAP M1 - Book, Section TI - Chapter 20. Reactive Arthritis A1 - Carter, John D. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintReactive Arthritis at a GlanceReactive arthritis is one of the spondyloarthritides. It is an inflammatory syndrome that typically begins 1–4 weeks after certain genitourinary or gastrointestinal infections.Most patients do not have the “classic triad” of symptoms (synovitis, urethritis, and conjunctivitis) and other organs are often involved (namely the skin).Key clinical features are asymmetric arthritis of a few joints, most often large joints of the lower extremities, often accompanied by axial arthritis and enthesitis typically at the Achilles tendon or plantar fascia and sacroiliac joints.Psoriasiform lesions on the soles—keratoderma blenorrhagicum—or penis—circinate balanitis—occur in one-third of patients and inflammatory eye disease is present in a similar proportion. Urethritis may occur with or without urogenital infection.HLA-B27 appears to increase disease susceptibility and chronicity of reactive arthritis, but recent data suggest it might portend more fulminate symptoms thereby serving as a diagnostic bias.Chlamydia, Salmonella, Campylobacter, Shigella, and Yersinia are definitive triggers of reactive arthritis, but other infections may also act as initiators.Although reactive arthritis often is self-limited in weeks to months, as many as 30%–50% of patients will develop chronic disease that often waxes and wanes. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56026584 ER -