TY - CHAP M1 - Book, Section TI - Chapter 18. Psoriasis A1 - Gudjonsson, Johann E. A1 - Elder, James T. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus PY - 2012 T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintPsoriasis at a GlanceWorldwide occurrence: Affects 2%–3% of Americans; prevalence ranges from 0.1% to 3% in various populations.A chronic disorder with polygenic predisposition combined with triggering environmental factors such as trauma, infection, or medication.Erythematous scaly papules and plaques; pustular and erythrodermic eruptions occur.Most common sites of involvement are scalp, elbows, knees, hands, feet, trunk, and nails.Psoriatic arthritis occurs in 10%–25% of patients; pustular and erythrodermic forms may be associated with fever.Pathology is characterized by uniform elongation of the rete ridges, with dilated blood vessels, thinning of the suprapapillary plate, and intermittent parakeratosis. Epidermal and perivascular dermal infiltrates of lymphocytes, with neutrophils occasionally in aggregates in the epidermis. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56025003 ER -