TY - CHAP M1 - Book, Section TI - Chapter 51. Primary Biliary Cirrhosis A1 - Pratt, Daniel S. A2 - Greenberger, Norton J. A2 - Blumberg, Richard S. A2 - Burakoff, Robert PY - 2012 T2 - CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 2e AB - Most patients with primary biliary cirrhosis (PBC) are asymptomatic at the time of diagnosis but eventually develop symptoms, including fatigue and pruritus.Consider PBC in any patient in whom liver enzymes are elevated in a cholestatic pattern; an isolated elevated alkaline phosphatase level always requires further evaluation.Antimitochondrial antibodies have 95% sensitivity for PBC and are central to the diagnosis. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/10/11 UR - accessmedicine.mhmedical.com/content.aspx?aid=55962008 ER -