TY - CHAP M1 - Book, Section TI - Chapter 37. Approach to the Patient with Jaundice & Abnormal Liver Tests A1 - Greenberger, Norton J. A2 - Greenberger, Norton J. A2 - Blumberg, Richard S. A2 - Burakoff, Robert PY - 2012 T2 - CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 2e AB - Jaundice is most often caused by decompensation of preexisting chronic liver disease, alcoholic hepatitis, and gallstone disease.Careful history, physical examination, and routine laboratory tests lead to accurate diagnosis in 85% of patients with jaundice.Cirrhosis can be diagnosed on the basis of two physical findings (asterixis, ascites) and two laboratory findings (decreased serum albumin [1.6]).Dilated intrahepatic bile ducts indicate obstruction from extrahepatic causes (stone, structure, tumor).Absence of dilated ducts in jaundiced patients with serum bilirubin >10 mg/dL suggests intrahepatic cholestasis.Sepsis, drugs, sickle cell disease, and chronic hepatitis are the most common causes of intrahepatic cholestasis. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=55960176 ER -