TY - CHAP M1 - Book, Section TI - Chapter 8. Hepatic Complications of Pregnancy A1 - Ukomadu, Chinweike A2 - Greenberger, Norton J. A2 - Blumberg, Richard S. A2 - Burakoff, Robert PY - 2012 T2 - CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 2e AB - Most liver biochemical tests are unchanged during pregnancy.Exceptions are albumin, total protein, and bilirubin (decreased) and alkaline phosphatase and cholesterol (increased).Several conditions unique to pregnancy may lead to hepatic impairment: Hyperemesis gravidarum, often in the first trimester, invariably before the 20th week of pregnancy.Intrahepatic cholestasis of pregnancy (IHCP), often in the third trimester (pruritus and mild liver tests abnormalities).Acute fatty liver disease of pregnancy (AFLP) in the third trimester (nausea and vomiting, jaundice, and oliguria; typically mild increase in transaminases, hyperbilirubinemia, coagulopathy, thrombocytopenia, and hypoglycemia).Preeclampsia (classic triad of hypertension, proteinuria, and edema) and eclampsia (preeclamptic triad plus seizures and coma) in the second or third trimester.HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), between the start of the third trimester and the immediate postpartum period, often manifesting with right upper quadrant pain, edema, and hypertension. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=55956076 ER -