TY - CHAP M1 - Book, Section TI - The Approach to Fever in the ICU A1 - Krishnan, Amita A1 - deboisblanc, Bennett P. A2 - Schmidt, Gregory A. A2 - Kress, John P. A2 - Douglas, Ivor S. PY - 2023 T2 - Hall, Schmidt and Wood’s Principles of Critical Care, 5th Edition AB - KEY POINTSUp to 70% of intensive care unit (ICU) patients will develop fever.Fever is a physiologic response where the body attempts to raise the thermoregulatory set point, whereas hyperthermia is a nonphysiologic disruption of thermoregulation.Approximately 50% of fevers are due to noninfectious causes, such as drug fevers, surgical trauma, and central nervous system injury.A thoughtful evaluation of a fever may reduce costs and lessen the potential risk to the patient.Although fever is associated with adverse outcomes in the ICU, there is no conclusive evidence to support the routine treatment of infectious fevers in nonbrain-injured patients.Extreme elevations of temperature (>41.1°C) in adults are most often due to noninfectious etiologies.Heat stroke, serotonin syndrome, neuroleptic malignant syndrome, and malignant hyperthermia are life-threatening causes of hyperthermia that must be immediately recognized and treated in order to avoid multisystem organ failure and death. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/11/13 UR - accessmedicine.mhmedical.com/content.aspx?aid=1201804975 ER -