TY  - CHAP
M1  - Book, Section
TI  - Hypersensitivity Pneumonitis
A1  - Mota, Prerna
A1  - Enelow, Richard I.
A2  - Grippi, Michael A.
A2  - Antin-Ozerkis, Danielle E.
A2  - Dela Cruz, Charles S.
A2  - Kotloff, Robert M.
A2  - Kotton, Camille Nelson
A2  - Pack, Allan I.
PY  - 2023
T2  - Fishman’s Pulmonary Diseases and Disorders, 6e
AB  - Hypersensitivity  pneumonitis  (HP)  is  an  interstitial  lung  disease  believed  to  be  mediated  by  aberrant  cellular  and  humoral  immune  responses  to  various  inhaled  antigens  in  susceptible  individuals,  resulting  in  inflammatory  and/or  fibrotic  disease  of  the  lung  parenchyma  and  small  airways.  Its  clinical  presentation  and  natural  course  can  be  quite  variable,  and  despite  the  efforts  of  numerous  expert  groups  and  panels,  clear  consensus  on  diagnostic  criteria  and  common  nomenclature  has  proven  elusive.  Previous  classification  schemes  described  “acute  HP”  and  “chronic  HP”  as  two  forms  of  the  disease,  the  latter  temporally  related  to  the  former,  despite  limited  evidence  to  support  this  approach.  The  recognition  that  prognosis  is  minimally  related  to  disease  duration,  and  is  more  dependent  upon  extent  of  fibrosis,  has  led  to  the  recent  move  to  reclassify  HP  subtypes  as  “nonfibrotic  HP”  and  “fibrotic  HP.”  The  latter  represents  a  uniquely  challenging  entity,  for  multiple  reasons  discussed  below.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/25
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1195005967
ER  -