TY - CHAP M1 - Book, Section TI - Carcinoma of the Anus A1 - Ursem, Carling A1 - McQuaid, Kenneth R. A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. PY - 2023 T2 - Current Medical Diagnosis & Treatment 2023 AB - The anal canal is lined from its proximal to distal extent by columnar, transitional, and non-keratinized squamous epithelium, which merges at the anal verge with the keratinized perianal skin.Cancers arising from the mucosa of the anal canal are relatively rare, comprising only 2% of all GI malignancies. Anal carcinoma occurred in an estimated 8590 patients in the United States in 2020, more commonly in women than men (2:1 ratio). Squamous cell carcinomas (SCC) make up the majority of anal cancers; adenocarcinomas account for the remainder but are uncommon. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/25 UR - accessmedicine.mhmedical.com/content.aspx?aid=1193162539 ER -