TY  - CHAP
M1  - Book, Section
TI  - Anticoagulants Overdose
A1  - Smollin, Craig
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2023
T2  - Current Medical Diagnosis & Treatment 2023
AB  - Warfarin  and  related  compounds  (including  ingredients  of  many  commercial  rodenticides,  the  so-called  superwarfarins  such  as  brodifacoum,  difenacoum,  and  related  compounds)  inhibit  the  normal  clotting  system  by  blocking  hepatic  synthesis  of  vitamin  K–dependent  clotting  factors.  After  ingestion  of  “superwarfarins,”  inhibition  of  clotting  factor  synthesis  may  persist  for  several  weeks  or  even  months  after  a  single  dose.  DOACs  include  the  direct  thrombin  inhibitor  dabigatran  and  the  factor  Xa  inhibitors  apixaban,  edoxaban,  and  rivaroxaban.  Some  of  these,  especially  dabigatran,  are  largely  eliminated  by  the  kidney  and  may  accumulate  in  patients  with  kidney  dysfunction.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1193161552
ER  -