TY  - CHAP
M1  - Book, Section
TI  - Paracoccidioidomycosis (South American Blastomycosis)
A1  - Rose, Stacey R.
A1  - Hamill, Richard J.
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2023
T2  - Current Medical Diagnosis & Treatment 2023
AB  - Paracoccidioides  brasiliensis  and  Paracoccidioides  lutzii  infections  have  been  found  only  in  patients  who  have  resided  in  South  or  Central  America  or  Mexico.  Long  asymptomatic  periods  enable  patients  to  travel  far  from  the  endemic  areas  before  developing  clinical  problems.  An  acute  form  of  the  disease  affects  predominately  younger  patients  and  involves  the  mononuclear  phagocytic  system,  resulting  in  progressive  lymphadenopathy.  A  more  chronic  form  affects  mostly  adult  men  and  predominately  involves  the  lung  as  well  as  the  skin,  mucous  membranes,  and  lymph  nodes.  Weight  loss,  pulmonary  complaints,  or  mucosal  ulcerations  are  the  most  common  symptoms.  Extensive  coalescent  ulcerations  may  eventually  result  in  destruction  of  the  epiglottis,  vocal  folds,  and  uvula.  Extension  to  the  lips  and  face  may  occur.  Lymph  node  enlargement  may  follow  mucocutaneous  lesions,  eventually  ulcerating  and  forming  draining  sinuses;  in  some  patients,  it  is  the  presenting  symptom.  Hepatosplenomegaly  may  be  present  as  well.  Patients  with  HIV  with  paracoccidioidomycosis  are  more  likely  to  have  extrapulmonary  dissemination  and  a  more  rapid  clinical  disease  course.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1193137527
ER  -