TY - CHAP M1 - Book, Section TI - Transient Ischemic Attacks A1 - Douglas, Vanja C. A1 - Aminoff, Michael J. A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. PY - 2023 T2 - Current Medical Diagnosis & Treatment 2023 AB - Key Clinical Updates in Transient Ischemic AttacksDual antiplatelet therapy with aspirin and clopidogrel for 90 days after a TIA or stroke due to 70–99% stenosis of an intracranial artery is recommended.The left atrial appendage is the source of embolism in most patients with atrial fibrillation. Several randomized trials showed percutaneous left atrial appendage closure was equivalent to anticoagulation in preventing stroke and systemic embolization, and several devices are approved for this indication in the United States and Europe. The procedure should be considered in patients with a contraindication to long-term anticoagulation, although short-term anticoagulation (45 days) followed by dual antiplatelet therapy (4.5 months) and then indefinite aspirin monotherapy is usually necessary after device placement.Kleindorfer DO et al. 2021 Stroke. [PMID: 34024117] SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1193128511 ER -