TY - CHAP M1 - Book, Section TI - Primary Adrenal Insufficiency (Addison Disease) A1 - Fitzgerald, Paul A. A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. PY - 2023 T2 - Current Medical Diagnosis & Treatment 2023 AB - ESSENTIALS OF DIAGNOSISDeficiency of cortisol and mineralocorticoid from destruction of the adrenal cortex.Weakness, vomiting, diarrhea; abdominal pain, arthralgias; amenorrhea.Increased skin pigmentation, especially of creases, pressure areas, and nipples.Hypovolemic hypotension.Hyponatremia; hyperkalemia; hypoglycemia; eosinophilia.Elevated plasma ACTH level; cosyntropin unable to stimulate serum cortisol to ≥ 20 mcg/dL (550 nmol/L).Acute adrenal crisis: above manifestations become critical, with fever, shock, confusion, coma, death. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/04 UR - accessmedicine.mhmedical.com/content.aspx?aid=1193160726 ER -