TY - CHAP M1 - Book, Section TI - Oxazolidinediones A1 - Gruenberg, Katherine A1 - Guglielmo, B. Joseph A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. PY - 2023 T2 - Current Medical Diagnosis & Treatment 2023 AB - Oxazolidinediones represent a class of antibacterials including linezolid and tedizolid. These agents are primarily active against aerobic gram-positive pathogens, including penicillin-resistant pneumococci, methicillin-resistant staphylococci and enterococci (both E faecalis and vancomycin-sensitive and vancomycin-resistant E faecium), and mycobacteria. Linezolid is bacteriostatic against all of these pathogens. Linezolid-resistant enterococci and VRE and linezolid-resistant S aureus and S epidermidis have been isolated. The oral bioavailability of these medications is complete, with serum levels approaching those observed with intravenous administration. The medications are eliminated primarily by nonrenal mechanisms. An advantage of tedizolid is that it can be administered once daily, whereas linezolid requires twice-daily dosing. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1193122183 ER -