TY - CHAP M1 - Book, Section TI - Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease A1 - Sharkey, Keith A. A1 - MacNaughton, Wallace K. A2 - Brunton, Laurence L. A2 - Knollmann, Björn C. PY - 2023 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition AB - The stomach has a number of critical functions in the processes of digestion: storage, digestion, and defense. The volume of the stomach is quite small at rest, but the gastric musculature can undergo receptive relaxation to accommodate a meal volume of 1 to 2 L. Food is broken down in the presence of acid by the grinding actions of the thick muscular coats of the stomach, and the contents then pass in a regulated manner into the duodenum. Gastric acid not only serves to facilitate digestion, but it also provides an effective antimicrobial milieu that facilitates defense against pathogens. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1193237984 ER -