TY - CHAP M1 - Book, Section TI - Membrane Transporters and Drug Response A1 - Giacomini, Kathleen M. A1 - Sugiyama, Yuichi A2 - Brunton, Laurence L. A2 - Knollmann, Björn C. PY - 2023 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition AB - Membrane transport proteins are present in all organisms. These proteins control the influx of essential nutrients and ions and the efflux of cellular waste, environmental toxins, drugs, and other xenobiotics (Figure 4–1). Consistent with their critical roles in cellular homeostasis, about 2000 genes in the human genome, or ~7% of the total number of genes, code for transporters or transporter-related proteins. The functions of membrane transporters may be facilitated (equilibrative, not requiring energy) or active (requiring energy). In considering the transport of drugs, pharmacologists generally focus on transporters from two major superfamilies, ABC and SLC transporters (Nigam, 2015). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/15 UR - accessmedicine.mhmedical.com/content.aspx?aid=1193226880 ER -