TY - CHAP M1 - Book, Section TI - Hemochromatosis A1 - Powell, Lawrie W. A1 - Frazer, David M. A2 - Loscalzo, Joseph A2 - Fauci, Anthony A2 - Kasper, Dennis A2 - Hauser, Stephen A2 - Longo, Dan A2 - Jameson, J. Larry PY - 2022 T2 - Harrison's Principles of Internal Medicine, 21e AB - Hemochromatosis is a relatively common inherited disorder of iron metabolism prevalent in European populations. Once thought to be a single disease entity, it is now known to be an iron-storage disorder with genetic heterogeneity but with a final common metabolic pathway resulting in the inappropriately high cellular release of iron. This leads to an increase in intestinal iron absorption and the deposition of excess iron in parenchymal cells with eventual tissue damage and organ failure. Thus, the term hemochromatosis now refers to a group of genetic diseases that predispose to iron overload, potentially leading to fibrosis and organ failure. Cirrhosis of the liver, diabetes mellitus, arthritis, cardiomyopathy, and hypogonadotropic hypogonadism are the major clinical manifestations. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/13 UR - accessmedicine.mhmedical.com/content.aspx?aid=1198718539 ER -