TY - CHAP M1 - Book, Section TI - Carcinoma of Unknown Primary A1 - Varadhachary, Gauri R. A1 - Raghav, Kanwal P. A1 - Huey, Ryan W. A2 - Kantarjian, Hagop M. A2 - Wolff, Robert A. A2 - Rieber, Alyssa G. PY - 2022 T2 - The MD Anderson Manual of Medical Oncology, 4e AB - KEY CONCEPTSCarcinoma of unknown primary (CUP) is defined as biopsy-proven metastatic cancer where a primary site is unidentifiable after adequate workup.CUP is a rare tumor with an incidence of less than 10 per 100,000 individuals and constitutes nearly 2% of all cancers diagnosed in the United States.Favorable and specific clinicopathologic subsets in CUP should be identified and treated with selective and aggressive treatments.Limited data support the use and therapeutic impact of molecular profiling assays for tissue of origin (ToO) determination in CUP.Chemotherapy for patients with CUP can be either empiric or site-specific (guided by putative primary site determined by clinicopathologic factors), and novel effective therapies for known primaries may impact the treatment decision.Overall prognosis in CUP is poor, but a great degree of heterogeneity based on patient and disease characteristics exists. SN - PB - McGraw Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1190838917 ER -