TY  - CHAP
M1  - Book, Section
TI  - Endemic Treponematoses
A1  - Lukehart, Sheila A.
A1  - Giacani, Lorenzo
A2  - Loscalzo, Joseph
A2  - Fauci, Anthony
A2  - Kasper, Dennis
A2  - Hauser, Stephen
A2  - Longo, Dan
A2  - Jameson, J. Larry
PY  - 2022
T2  - Harrison's Principles of Internal Medicine, 21e
AB  - The  endemic  treponematoses  are  chronic  diseases  that  are  transmitted  by  direct  contact,  usually  during  childhood  and,  like  syphilis,  can  cause  severe  late  manifestations  years  after  initial  infection.  These  diseases  are  caused  by  very  close  relatives  of  Treponema  pallidum  subspecies  pallidum,  the  etiologic  agent  of  venereal  syphilis  (Chap.  182).  Yaws,  pinta,  and  endemic  syphilis  (bejel)  have  traditionally  been  distinguished  from  venereal  syphilis  by  mode  of  transmission,  age  of  acquisition,  geographic  distribution,  and  clinical  features;  however,  there  is  overlap  for  each  of  these  factors.  Our  “knowledge”  about  these  infections  is  based  on  observations  by  health  care  workers  who  have  visited  endemic  areas  during  the  past  70  years.  Except  for  the  ongoing  programs  of  mass  drug  administration  (MDA)  for  yaws  eradication  promoted  by  the  World  Health  Organization  (WHO),  virtually  no  well-designed  studies  of  the  natural  history,  diagnosis,  or  treatment  of  these  infections  have  been  conducted.  The  classically  defined  treponemal  infections  are  compared  and  contrasted  in  Table  183-1.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1198223136
ER  -