TY - CHAP M1 - Book, Section TI - Transfusion Therapy and Biology A1 - Tiberghien, Pierre A1 - Garraud, Olivier A1 - Chiaroni, Jacques A2 - Loscalzo, Joseph A2 - Fauci, Anthony A2 - Kasper, Dennis A2 - Hauser, Stephen A2 - Longo, Dan A2 - Jameson, J. Larry PY - 2022 T2 - Harrison's Principles of Internal Medicine, 21e AB - Transfusion encompasses the use of blood components (BCs) to prevent or treat anemia, hemorrhage, and bleeding disorders. Occasionally, BCs may be used to treat infection or relapse of malignant blood diseases after allogeneic hematopoietic transplantation. BCs comprise mainly red blood cell concentrates (RBCCs), platelet concentrates (PCs), and plasma for transfusion use (as opposed to plasma for fractionation into medicinal products such as albumin and immunoglobulin). Alongside transfusion safety, ensuring BC quality, assessing in vivo efficacy, and promoting evidence-based transfusion practices are critical aspects of transfusion medicine. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1190475306 ER -