TY - CHAP M1 - Book, Section TI - Drugs Used in Tuberculosis and Leprosy A1 - Stringer, Janet L. PY - 2022 T2 - Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 6e AB - The mycobacteria that cause tuberculosis and leprosy are very slow growing, so therapy must be continued for relatively long periods of time. The cell wall of these bacteria is more than 60% lipid, mostly mycolic acids. To prevent the emergence of resistant strains, it is vital to employ combination therapy with as many as four or five agents to which the organism is sensitive. The current treatment regimen for tuberculosis (TB) (which is subject to change) is 2 months of isoniazid, rifampin, pyrazinamide, and ethambutol, followed by 4 months of isoniazid and rifampin. Increasing the duration of therapy or changing the choice of drugs depends on culture and sensitivity results and factors that increase risk of treatment failure. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1187634228 ER -