TY - CHAP M1 - Book, Section TI - Protein Synthesis Inhibitors A1 - Stringer, Janet L. PY - 2022 T2 - Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 6e AB - Protein synthesis machinery, including ribosomes, is somewhat different in bacteria compared to mammalian cells. This accounts for the selectivity of this group of drugs for bacteria. Some textbooks and instructors make a point of having students know which ribosomal subunit a class of drugs binds to. However, this is not of primary importance. If you already know it, try not to forget it. If you are struggling with the antimicrobials at this point, save this fact for later. These drugs require binding to an intracellular protein (ribosomal subunit). Therefore, the drugs need to gain entry into the cell. A major route of resistance for the bacteria is to block the movement of the drugs into the cell. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/13 UR - accessmedicine.mhmedical.com/content.aspx?aid=1187634167 ER -