TY - CHAP M1 - Book, Section TI - Major Histocompatibility Complex & Transplantation A1 - Levinson, Warren A1 - Chin-Hong, Peter A1 - Joyce, Elizabeth A. A1 - Nussbaum, Jesse A1 - Schwartz, Brian PY - 2022 T2 - Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 17e AB - In transplantation, an organ or tissue from one person is “grafted” to another person. A major barrier to the success of these life-saving procedures is the immune system, which attacks any cells it sees as foreign. Graft survival is largely determined by the donor’s and recipient’s major histocompatibility complex (MHC) proteins, which present antigens to T cells. In humans, these proteins are encoded by the human leukocyte antigen (HLA) genes. (Note that we will use MHC and HLA interchangeably.) Three of these genes (HLA-A, HLA-B, and HLA-C) code for the class I MHC proteins. Several HLA-D loci determine the class II MHC proteins (i.e., DP, DQ, and DR) (Figure 62–1). The features of class I and class II MHC proteins are compared in Table 62–1. If the HLA proteins on the donor’s cells differ from those on the recipient’s cells, then an immune response occurs in the recipient. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1190864828 ER -