TY  - CHAP
M1  - Book, Section
TI  - Antibacterial Drugs: Resistance
A1  - Levinson, Warren
A1  - Chin-Hong, Peter
A1  - Joyce, Elizabeth A.
A1  - Nussbaum, Jesse
A1  - Schwartz, Brian
PY  - 2022
T2  - Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 17e
AB  - There  are  four  major  mechanisms  that  mediate  bacterial  resistance  to  drugs  (Table  11–1).  (1)  Bacteria  produce  enzymes  that  inactivate  drugs.  (2)  Bacteria  synthesize  modified  targets  against  which  the  drug  has  a  reduced  effect.  (3)  Bacteria  reduce  permeability  to  the  drug  such  that  an  effective  intracellular  concentration  of  the  drug  is  not  achieved.  (4)  Bacteria  actively  export  drugs  using  a  “multidrug-resistance  pump.”  The  multidrug-resistant  (MDR)  pump  imports  protons  and,  in  an  exchange-type  reaction,  exports  a  variety  of  foreign  molecules  including  certain  antibiotics,  such  as  tetracyclines.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/23
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1190859653
ER  -