TY  - CHAP
M1  - Book, Section
TI  - Genetics in Disorders of Multifactorial Causation
A1  - Pyeritz, Reed E.
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2022
T2  - Current Medical Diagnosis & Treatment 2022
AB  - Many  disorders  cluster  in  families  but  are  not  associated  with  evident  chromosomal  aberrations  or  mendelian  inheritance  patterns.  Examples  include  congenital  malformations  such  as  cleft  lip,  pyloric  stenosis,  and  spina  bifida;  coronary  artery  disease;  type  2  diabetes  mellitus;  and  various  forms  of  neoplasia.  They  are  often  characterized  by  varying  frequencies  in  different  racial  or  ethnic  groups,  disparity  in  sexual  predilection,  and  greater  frequency  (but  less  than  full  concordance)  in  monozygotic  than  in  dizygotic  twins.  This  inheritance  pattern  is  called  "multifactorial"  to  signify  that  multiple  genes  interact  with  various  environmental  agents  to  produce  the  phenotype.  The  familial  clustering  is  assumed  to  be  due  to  sharing  of  both  alleles  and  environment.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1184181589
ER  -