TY  - CHAP
M1  - Book, Section
TI  - Salicylates Overdose
A1  - Smollin, Craig
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2022
T2  - Current Medical Diagnosis & Treatment 2022
AB  - Salicylates  (aspirin,  methyl  salicylate,  bismuth  subsalicylate,  etc)  are  found  in  a  variety  of  over-the-counter  and  prescription  medications.  Salicylates  uncouple  cellular  oxidative  phosphorylation,  resulting  in  anaerobic  metabolism  and  excessive  production  of  lactic  acid  and  heat,  and  they  also  interfere  with  several  Krebs  cycle  enzymes.  A  single  ingestion  of  more  than  200  mg/kg  of  salicylate  is  likely  to  produce  significant  acute  intoxication.  Poisoning  may  also  occur  as  a  result  of  chronic  excessive  dosing  over  several  days.  Although  the  half-life  of  salicylate  is  2–3  hours  after  small  doses,  it  may  increase  to  20  hours  or  more  in  patients  with  intoxication.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1184179875
ER  -